IL-33/ST2信号通路在心血管疾病中的研究进展

Research progress of the IL-33/ST2 pathway in cardiovascular diseases

可溶性ST2蛋白(s ST2)是IL-1受体家族的成员,IL-33是ST2的特异性配体,IL-33/ST2信号通路在炎症反应和免疫疾病中发挥着重要作用;已经证实ST2是一种心肌蛋白,在张力负荷增加的心肌细胞中表达增多,可阻断IL-33抗心肌细胞肥大和心肌纤维化的作用,导致心肌重构。研究发现ST2参与了动脉硬化过程,使高血压的发生风险增加;高浓度的s ST2与冠心病和心力衰竭的活动性和预后相关;醛固酮受体拮抗剂在IL-33/ST2信号通路的起着重要作用。

Soluble ST2(sST2) is a protein of interleukin-1(IL-1) receptor family, IL-33 is the special ligand of ST2, IL-33/ST2 signaling has a significantly effect in the inflammation and immunology diseases. It certified that ST2 can be secreted by the myocardial cells on the mechanical overload, and it can inhibit the anti-hypertrophy and anti-fibrosis of IL-33, can induce the cardiac remodeling. New researches indict that ST2 effects on the process of atherosclerotic and is associated with incident hypertension. Higher s ST2 is related to disease activity and adverse in coronary artery disease and heart failure. Aldosterone receptor antagonist plays an important role in the IL-33/ST2 pathway.