结核病与精神障碍共病的相关因素浅探

A review of clinical correlates of tuberculosis and psychiatric co-morbidity

结核病与精神障碍均是我国乃至全世界的高负担疾病,严重影响和危害人类的健康。两者之间复杂而密切的共病相关因素,涉及诸多方面的问题,如共病时具有的相同危险因子,抗结核药物所致精神障碍,抗结核药物对精神科药物代谢的影响,某些抗精神病药物的抗结核效应等。无论是结核科的还是精神科的医师,探讨和重视两者之间的这些关系和特点,对完善结核病合并精神障碍的诊断与治疗、减少药物不良反应的发生和提高患者对长期治疗与康复的依从性等都有极其重要的临床意义。本文就结核病与精神障碍共病的相关因素进行综述。

Both tuberculosis and psychiatric disorder, which greatly threaten the health of human being, have high burden of disease not only in China but also all over the world. Complex and close clinical relationship have been found between tuberculosis and its frequent psychiatric co-morbidity, including several issues: both diseases sharing common risk factors, psychiatric side effects of anti-tuberculous agents, interactions between anti-tuberculous agents and medications used for psychiatric disorder, potentials of anti-psychosis agents developed in the treatment of tuberculosis, psychosocial factors in tuberculosis. It is critical to attach significant importance to the interplay between both diseases for enhancing treatment response, reducing side effects and improving treatment adherence, whether physicians or psychiatrists.