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白细胞介素33与乳腺癌关系的研究进展 被引量：1

Research progress of the relationship between IL-33 and breast cancer
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摘要 白细胞介素(IL)33作为IL-1家族的新成员,主要通过改变肿瘤微环境影响乳腺癌的进程。以往研究表明,IL-33主要通过Th2型免疫反应使机体产生免疫抑制而促进乳腺癌发生;近年研究表明,IL-33可通过促进Th1型和CD8+T细胞应答,发挥抗乳腺肿瘤作用。现就IL-33在乳腺癌中的研究进展作一综述。 Interleukin-33(IL-33) is a new member of IL-1 family, which impacts progress of breast cancer by changing tumor micro-environment. Previous studies demonstrated that IL-33 induced body immune-suppression mainly mediated by Th2-type immune response, thus promoting breast cancer development; recent studies indicated that IL-33 could exert anti-breast tumor effect by promoting Th1-type and CD8+ T cell response. Now research progress of IL-33 in breast cancer was summarized here.
作者 李玉容 莫世友 刘新福 张辉
机构地区 南华大学附属邵阳医院肿瘤内科
出处 《中华临床医师杂志（电子版）》 CAS 2016年第16期2503-2506,共4页 Chinese Journal of Clinicians(Electronic Edition)
基金 南华大学研究生科研创新项目(2016XCX56)
关键词 白细胞介素33 乳腺癌 肿瘤微环境 免疫调节 Interleukin-33 Breast cancer Tumor micro-environment Immunoregulation
分类号 R737.9 [医药卫生—肿瘤]
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参考文献23

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二级参考文献44

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中华临床医师杂志（电子版）
2016年 第16期

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