高龄老年高血压患者高尿酸血症相关因素分析

Prevalence and analysis of hyperuricemia among elderly patients with essential hypertension

目的了解高龄老年(≥80岁)原发性高血压患者高尿酸血症的患病率情况及相关因素。方法从广东省慢病防治示范基地东莞寮步镇选取资料完整的高龄老年原发性高血患者,抽取空腹血液检测尿酸、血生化等指标,分析高龄老年高血压患者高尿酸血症的患病率情况,同时用Logistic回归进行高尿酸血症发生相关因素分析。结果共入选资料完整的高龄老年原发性高血压患者583例,尿酸水平为(389.42±102.34)μmol/L,总患病率为50.1%,其中男性患病率为49.5%,女性患病率为50.4%,总体男性高尿酸血症患病率与女性差异无统计学意义(χ2=0.042,P=0.838);Logistic回归分析表明高甘油三酯、BMI、收缩压和肾小球滤过率为高龄老年高血压患者高尿酸血症发生的危险因素(P<0.05),空腹血糖和高密度脂蛋白胆固醇为高尿酸血症发生的保护因素(P<0.05)。结论高龄老年原发性高血压患者高尿酸血症患病率高,且与收缩压、高密度脂蛋白胆固醇、甘油三酯、空腹血糖、BMI和肾小球滤过率相关。

Objective To understand the prevalence and association of hyperuricemia in elderly patients(aged≥80 years old) with essential hypertension. Methods All participants with essential hypertension were from the community of Liaobu, Dongguan, Guangdong Province. And all of them were extracted the fasting blood uric acid, blood biochemical indicators, hepatic and renal function, serum lipid and fasting blood-glucose for analyzing and the differences prevalence between men and women were compared. The Logistic regression was used to analyze the associated risk factors with hyperuricemia. Results There were total of 583 essential hypertension with data integrity, the mean value of uric acid was(389.42±102.34)μmol/L, the total prevalence of hyperuricemia was 50.1%, there were no statistical difference between men and women(49.5% vs. 50.4%, χ2=0.042, P=0.838). Logistic regression analysis showed that triglyceride, glomerular filtration rate, systolic blood pressure and body mass index were risk factors for hyperuricemia, but fasting blood-glucose and high-density lipoproteincholesterol were protective factors for hyperuricemia. Conclusions The prevalence of hyperuricemia among essential hypertension of elderly patients was very high, and associated with triglyceride, glomerular filtration rate, systolic blood pressure, body mass index, fasting blood-glucose and high-density lipoprotein cholesterol.