非酒精性脂肪性肝病发病机制的研究现状

Research advances in the pathogenesis of nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是目前全球最常见的慢性肝病,其发病率逐年上升。近十年的研究表明,NAFLD是一种多系统疾病,影响肝脏以外的器官代谢和免疫通路的作用,是代谢综合征在肝脏的表现,其发病机制尚不明确,目前认为与血脂异常、胰岛素抵抗以及氧化应激、内质网应激相关。本综述针对NAFLD的发病机制的研究现状进行简单阐述。

Nonalcoholic fatty liver disease(NAFLD) is currently the world's most common chronic liver disease, its incidence increased year by year. Nearly a decade of research shows that NAFLD is a multisystem disease and a manifestation of the metabolic syndrome in the liver, affecting organs metabolism except for liver and immunity. However, the pathogenesis is poorly understood, now it's thought to be associated with dyslipidemia, insulin resistance(IR) and oxidative stress, endoplasmic reticulum stress( ERS). This article made a review about the pathogenesis of NAFLD.