低氧诱导因子在调节椎间盘髓核细胞功能中的研究进展

Recent progress on the action mechanism of hypoxia-inducible factor in regulating function of nucleus pulposus cells

椎间盘退变性疾病引起的颈、肩、腰、腿痛已经严重影响人类日常生活,给社会造成了严重的经济负担,但目前治疗效果不佳。既往研究结果表明,髓核细胞代谢活动、低氧诱导因子含量的变化均能影响椎间盘退变。现在人们已经开始从组织工程学上来探讨椎间盘退变性疾病的治疗,希望找到有效方法来阻止椎间盘退变甚至能够逆转椎间盘退变的方法。椎间盘的一个显著特点就是氧含量低,而低氧诱导因子能够使机体很好地适应低氧环境。目前研究表明,低氧诱导因子能够调节髓核细胞的生物学功能,并且可能成为阻止椎间盘退变进展甚至逆转椎间盘退变的关键因素。本文就低氧诱导因子对髓核细胞代谢、细胞外基质表达、细胞凋亡、细胞自噬的调控作一综述。

The disease of intervertebral disc degeneration(IDD) had serious influences in daily life, and had a badly economic burden to society. In addition, there are not perfect solutions to cure this disease. Previous research results imply that either metabolic activity of nucleus pulposus(NP) cells or the content change of low oxygen tension plays a crucial role in IDD. Now, people hope to find an effective method to prevent IDD and reverse this phenomena by targeting tissue engineering. Low oxygen tension is a remarkable character in intervertebral disc, but organism with hypoxia-inducible factor-1 α(HIF) have a better ability to adapt to the hypoxia environment. Current research indicates that the biological function of NP cells can be adjusted by HIF, which may be a critical factor that impede and inverse the progress of IDD. In this study, we depicted the roles of HIF in regulation of metabolic activity of NP cells, expression of extracellular matrix, cell apoptosis and cell autophage.