SDF-1/CXCR4轴与糖尿病伴骨性关节炎的研究现状

Current research status of the relationship between SDF-1/CXCR4 axis and diabetes mellitus associated with osteoarthritis

随着糖尿病发病率的急剧攀升,其复杂多样的并发症给社会带来了沉重的医疗负担,糖尿病性骨关节病就是其中一种。骨性关节炎与糖尿病能够互相促进彼此的生物功能,关系密切,但其机制尚未明确。近年来发现基质细胞衍生因子-1(stromal cell-derived factor-1,SDF-1)/CXCR4(chemokine receptor-4)轴通过介导免疫炎症反应、破坏血管内皮功能、促进病理性血管形成、损伤外周神经系统等作用在糖尿病伴骨性关节炎的发生发展中发挥重要作用,其靶向治疗成为研究的新热点,本文就SDF-1/CXCR4轴与糖尿病伴骨性关节炎的作用作简要综述,拟在为糖尿病伴骨性关节炎的药物治疗提供新视角。

With the sharp rise in incidence of diabetes, its complications pose a serious healthy burden. Osteoarthritis is one of them. Osteoarthritis and diabetes mellitus are close to each other as they can promote their respective functions, but its mechanism is not yet clear. In recent years it is found that the stromal cell-derived factor 1(SDF-1)/chemokine receptor-4(CXCR4) axis play an important role in development and incidence of osteoarthritis through immune inflammatory reaction, damage to the endothelial function, promoting the pathological blood vessel formation, damage to the peripheral nervous system in diabetes mellitus with osteoarthritis, as a result, its targeted therapy become the hot topic of the researches. This paper reviewed briefly on the role of the SDF-1/CXCR4 axis, aimed to provide a new perspective of drug therapy for diabetes mellitus with osteoarthritis.