新生儿高胆红素血症与细胞因子关系的研究进展

Research progress about neonatal hyperbilirubinemia and cytokines

目前新生儿高胆红素血症的发病率仍很高,可引起机体多脏器损害,而且发病机制仍不清楚。近年来研究发现,高胆红素是一种潜在的免疫毒性物质,高胆红素血症患儿体内存在T淋巴细胞增殖与分化受到抑制及T淋巴细胞亚群功能失调,同时胆红素升高可以导致细胞因子的分泌出现紊乱,故深入开展新生儿高胆红素血症免疫机制研究,做到早期诊断及早期干预,尤其预防胆红素脑病的发生有着重要的意义。

At present, the incidence of neonatal hyperbilirubinemia is still very high. It can cause multiple organ damage, and the pathogenesis is still not clear. In recent years, the studies have found that high bilirubin is a potential immune toxic substance, the proliferation and differentiation of T cells are inhibited and T cell subsets are dysfunctional in hyperbilirubinemia. At the same time, high bilirubin can lead to cytokines secretion disorders. To study immune mechanism of neonatal hyperbilirubinemia in-depth has very important significance, it may do early diagnosis and early intervention, especially to prevent the occurrence of bilirubin encephalopathy.