阿片生长因子及其受体抗肿瘤机制研究进展

Research progress of opioid growth factor and its receptor on anti-tumor

阿片生长因子作为一种内源性阿片肽,不仅可调节细胞更新、伤口愈合、血管形成及发育等活性和功能,而且因其与特异性受体结合可产生的抗肿瘤作用,所以其抗肿瘤作用日益受到重视。它具有持续表达、自分泌、抑制肿瘤细胞增殖的功能。其抑制细胞生长具有立体定向、无细胞毒性、诱导非凋亡、非固着依赖、依赖RNA和蛋白合成等特点,在生理浓度发挥生物学活性。阿片生长因子及其受体抗肿瘤分子机制多种多样,例如它可抑制肿瘤细胞DNA合成,通过多种通路产生抗肿瘤作用,并在动物实验及临床应用方面取得了突破性进展,既可以作为一种主要疗法单独治疗肿瘤,又可以联合其他药物治疗肿瘤,临床上有广阔的应用前景。

As a endogenous opioid peptide, opioid growth factor not only can regulate cell renewal, wound healing, angiogenesis and development activity, but its anti-tumor effect is becoming more and more attention because of binding the specific receptor. it is constitutively expressed, autocrine produced, inhibit tumor proliferation. The action of opioid growth factor are stereospecific, noncytotoxic,nonapoptotic, anchorage-independent, reliant on RNA and protein synthesis,it occurring at physiologically relevant concentrations. A variety of its anti-tumor mechanism, for example, it can inhibit DNA synthesis of tumor cell, through multiple pathways to produce antitumor effects, it made breakthrough progression in animal experiments and clinical, it can not only as a main therapy but can be combined with other drugs in the treatment of tumor. Opioid growth factor and its receptor has broad application on clinical.