急性百草枯中毒致肺损伤中细胞因子作用的研究进展

Research advances of cytokines in the process of lung injury induced by paraquat

百草枯可通过皮肤、呼吸道、消化道侵入人体各组织,尤其是肺组织(具有嗜肺性的特征),导致不同程度的急性中毒和肺组织损伤。肺损伤主要表现为:早期肺泡上皮细胞受损、肺泡内出血水肿、炎症细胞浸润等;晚期出现肺泡腔部分或完全溶解及肺间质纤维化。百草枯中毒目前尚无特效解毒药剂,一旦中毒病死率极高。越来越多的研究表明,有大量细胞因子参与该损伤过程。本文概述各细胞因子在百草枯致肺损伤进程中的作用机制,总结当前研究现状并为后续解毒药物研发及治疗新方法的探索提供参考。

The paraquat can invade human tissue through skin, respiratory tract and alimentary canal so as to cause acute poisoning including lung injury. The lung injury manifests mainly as follows: alveolar epithelial cell damage, alveolar hemorrhage edema and inflammatory cell infiltration in early injury, alveolar partial or complete dissolution and pulmonary interstitial fibrosis lately. There is no effective antidote for paraquat, therefore, the mortality of paraquat is very high. Recently, more and more researches indicated that cytokines played important roles in this process. This article reviews the interaction mechanisms of cytokines in the process of lung injury induced by paraquat and summarized current researches so as to provide references in investigating new treatments and antidotes.