双磷酸盐抗肿瘤机制最新研究概况

New research program of antitumor mechanism with bisphosphonates

第三代双磷酸盐—唑来膦酸(ZOL)通过抑制破骨细胞活性而抗骨吸收从而达到增强骨质,改善骨质疏松的作用已得到广泛证实,且发现在骨转移患者中ZOL有预防或延迟骨相关事件(SREs)发生的作用,多个大型临床实验证明ZOL可潜在提高患者生活质量。现如今,大量研究显示出ZOL具有多机制介导的抗瘤活性,本文重点阐述ZOL在诱导细胞凋亡、影响肿瘤微环境、调节免疫细胞、调控细胞因子等方面的抗肿瘤作用及机制。随着ZOL抗肿瘤作用机制的进一步阐明,其在肿瘤临床治疗中将具有广阔的应用前景。

The third generation of bisphosphonates(BPs)-zoledronate(ZOL) by inhibiting osteoclast activity and resistance to bone resorption to bone, improve the effect of osteoporosis has been confirmed, and found that ZOL had prevented or delayed in patients with bone metastases of skeletal-related events(SREs), several large-scale clinical trials proved that ZOL can potentially improve the patients quality of life. Nowadays, a lot of research shows that ZOL has multiple mechanisms mediated antitumor activity. This paper mainly expounds ZOL in inducing cell apoptosis, tumor microenvironment, regulating immune cells, regulation of cytokines and other aspects of the antitumor function and mechanism. With ZOL antitumor mechanisms to further clarify, it will has a broad development in clinical application.