前列地尔在心血管疾病的临床应用

Clinical application of alprostadil in the cardiovascular diseases

作为一种高生物活性药物,前列地尔的主要成分是前列腺素E1(PGE1)。PGE1是内源性的生物活性物质之一,具有抗血小板聚集、抗血栓形成、舒张血管平滑肌、保护细胞、改善微循环等诸多生物学功能。前列地尔能够改善冠心病、高血压病、心力衰竭、高脂血症、肺源性心脏病等患者的预后,因而在心血管疾病的治疗中具有很高的临床应用价值。文章综述了前列地尔的生理学和药理学作用机制以及在心血管疾病治疗中的研究进展,为临床应用提供参考。

As an efficient bioactive drug, the main component of alprostadil is prostaglandin E1(PGE1). PGE1 is one of the endogenous bioactive substances which has many biological functions such as anti-platelet aggregation, anti-thrombosis, relaxing vascular smooth muscle, protecting the cells, improving the microcirculation, and so on. Alprostadil could improve the prognosis of patients with coronary heart disease, hypertension disease, heart failure, hyperlipidaemia and cor pulmonale, so that it possesses a higher value in the treatment of cardiovascular diseases. The article made an overview on these aspects: the physiological and pharmacological mechanism of action, and the research progress in the treatment of cardiovascular diseases, in order to provide reference to clinical application.