早期新生儿与足月新生儿胼胝体长度的比较研究

Comparative study on the length of corpus callosum in early-term neonates and full-term neonates

目的比较早期新生儿与足月新生儿胼胝体长度(CC-L),探讨CC-L在新生儿大脑发育评价中的临床应用价值。方法随机选取本院孕37~40+6周出生的单胎新生儿97例,平均孕周(39.29±1.14)周,平均体质量(3 374±412)g。按孕周分为早期新生儿组(孕37~38+6周出生)及足月新生儿组(孕39~40+6周出生)。所有新生儿于出生后24 h内进行颅脑超声检查,测量并比较两组CC-L是否具有统计学差异,统计并分析性别和体质量与CC-L的关系。结果足月新生儿的平均孕周、体质量、CC-L分别为(39.98±0.67)周、(3 495±365)g、(44.89±2.27)mm;早期新生儿的平均孕周、体质量、CC-L分别为(38.20±0.67)周、(3 170±406)g、(43.68±1.33)mm,足月新生儿体质量、CC-L均高于早期新生儿组,差异具有统计学意义(P<0.05)。新生儿的CC-L与体质量、性别均无明显相关性。结论足月新生儿比早期新生儿CC-L更长,大脑发育更好,在孕37周以上出生的正常新生儿中,体质量并不是大脑发育的重要因素。

Objective To compare the corpus callosum length(CC-L) in early-term neonates and full-term neonates, and to discuss the value of these parameters in evaluation of neonatal brain development. Methods Ninety-seven neonates, born between 37-40+6 weeks, were enrolled in this prospective study. The mean gestational age and the mean weight were(3 374±412) g and(39.29±1.14) weeks. 44 cases in early-term neonates(born between 37-38+6 weeks) and 53 cases in full-term neonates(born between 39-40+6 weeks). All neonates did cranial ultrasound examination in 24 hours after birth, CC-L were measured and compared between the two groups, analyzed the relationship between gender, body weight and CC-L. Results The mean gestational week, mean weight and mean CC-L of early-term neonates were(39.98±0.67) weeks,(3 495±365) g,(44.89±2.27) mm, the mean gestational week, mean weight, mean CC-L of full-term neonates were(38.20±0.67) weeks,(3 170±406) g and(43.68±1.33) mm, the mean weight, mean CC-L of full-term neonates were higher than early-term neonates(P<0.05). CC-L were not significantly correlated with body weight, gender. Conclusions CC-L of full-term neonates is longer than early-term neonates. Suggested that full-term neonates brain development was better than early-term neonates. In full-term and early-term neonates, weight is not the important factor in brain development.