血清Betatrophin预测非酒精性脂肪肝及其进展的作用

Function of Betatrophin in the prediction of nonalcoholic fatty liver and its progress

目的研究促代谢因子(Betatrophin)在预测非酒精性脂肪肝(NAFLD)及其进展中的作用。方法 249例受试者进行超声定量脂肪含量(LFC)测定,分为三组:正常对照组:LFC<9.15%84例;低脂肪含量脂肪肝组(LLFC):9.15%≤LFC≤20%82例;高脂肪含量脂肪肝组(HLFC):LFC>20%83例,收集受试者的临床资料,空腹抽静脉血检测血清Betatrophin及相关临床指标。采用单因素方差分析比较三组间各指标差异,Pearson相关分析Betatrophin与各指标间的相关性,多元线性逐步回归分析影响LFC的独立因素。结果 (1)正常对照组、LLFC、HLFC三组血清Betatrophin水平分别为253.95(117.96~419.53)pg/ml,250.82(104.27~422.79)pg/ml,286.47(110.77~431.86)pg/ml,HLFC组Betatrophin水平较正常对照组、LLFC组有明显升高,差别有统计学意义(P<0.05)。(2)相关分析显示,校正性别、年龄后Betatrophin与LFC呈正相关(r=0.213,P<0.01)。(3)多因素线性回归分析显示,血清Betatrophin水平是LFC独立影响因素(t=2.561,P<0.05)。结论血清Betatrophin是NAFLD及其进展的独立危险因素,临床检测Betatrophin有助于对进展期NAFLD人群早期识别、干预,改善预后。

Objective To study the function of Betatrophin in the prediction of nonalcoholic fatty liver(NAFLD) and its progress. Methods A total of 249 subjects based on ultrasonic quantitative determination of fat content(LFC) were divided into three groups, control(LFC<9.15%, n=84), LLFC(9.15%≤LFC≤20%, n=82) and HLFC(LFC>20%, n=83). Anthropometric and biochemical examinations were performed. Betatrophin and clinical factors were measured by ELISA Kit. One-way ANOVA, Pearson correlation analysis and multivariate linear regression analysis were used to analyze the results. Results The levels of Betatrophin in control group, LLFC group and HLFC group were 253.95(117.96-419.53) pg/ml, 250.82(104.27-422.79) pg/ml, 286.47(110.77-431.86) pg/ml, respectively. Betatrophin levels in HLFC group increased significantly compared with control group and LLFC group(P<0.05). Serum Betatrophin showed significant differences in the three groups(P<0.01). Adjusted by gender and age, serum Betatrophin levels were positively correlated with LFC(r=0.213, P<0.01). Multivariate linear regression analysis showed that the serum Betatrophin level was an independent risk factor for the LFC(t=2.561, P<0.05). Conclusions Betatrophin is an independent risk factor for NAFLD and its progress. Checking serum Betatrophin is helpful for the early diagnosis of NAFLD and improvement of prognosis.