蛛网膜下腔出血炎症反应研究进展

Advance of inflammatory response in subarachnoid hemorrhage

蛛网膜下腔出血(SAH)是一种急危重症,致残致死率高。早期脑损伤(EBI)及迟发性脑损伤(DBI)是导致患者不良预后的主要原因。随着对EBI及DBI病理生理机制的不断研究,学者们认为二者可能是疾病在不同阶段的不同表现形式,具体机制有很多相似之处。炎症反应已经被证明贯穿SAH的发生发展,且炎症反应的程度同患者预后显著相关。在动物实验中,炎症反应抑制剂的使用也均取得了较好的效果。本文就蛛网膜下腔出血后炎症反应的研究进行综述。

Subarachnoid hemorrhage(SAH) is a kind of acute and severe disease with high morbidity and mortality. Early brain injury(EBI) and delayed brain injury(DBI) are the main causes of poor prognosis. With continuous studies of EBI and DBI, it is believed that the two share many similar mechanisms and may just be different manifestations of SAH in different stages. Inflammatory response has been shown to be associated with the occurrence and development of SAH, and the degree of inflammation is significantly associated with the prognosis of SAH patients. In animal experiments, the use of inflammatory response inhibitors have also achieved good results. This article reviewed the study of inflammatory response after SAH.