胃食管反流病的特点及与牙周疾病相关性研究

Study on the correlation between gastroesophageal reflux disease and periodontitis

目的探讨胃食管反流病(GERD)的流行病学特点及与牙周疾病之间的关系。方法对于2014年4月至2016年4月就诊于新疆维吾尔自治区人民医院口腔科的80例GERD患者和71名正常人进行GERD相关检查和牙周疾病检查,牙周检查以社区牙周指数(CPI)和附着丧失(AL)作为诊断标准。结果 GERD患者与对照组比较,年龄、性别等指标之间无统计学差异(P>0.05),而民族、BMI、吸烟比例等指标之间有统计学差异(P<0.05),GERD患者中维吾尔族较汉族多(χ~2=4.447,P=0.035),BMI高于对照组(t=2.463,P=0.015),GERD组吸烟比例较对照组高(χ~2=5.234,P=0.022),GERD患者牙周炎患病率较对照组高(χ~2=4.113,P=0.043),在GERD患者中牙周炎严重程度较对照组高。通过Logistics回归分析可知年龄是牙周炎的危险因素(OR=1.091,95%CI 1.052~1.132),非GERD(OR=0.332,95%CI 0.176~0.624)和不吸烟(OR=0.422,95%CI 0.210~0.847)是牙周疾病的保护因素。结论与吸烟、年龄等危险因素一样,GERD是牙周疾病的危险因素之一。

Objective To investigate the epidemiological characteristics of gastroesophageal reflux disease(GERD),and the correlation with the periodontitis.Methods 80 GERD patients and 71 healthy people were selected dated from April 2014 to April 2016,all patients were given periodontal examination according to the diagnostic criteria of community periodontal index(CPI) and attachment loss level(AL).Results There was no statistically significant differences among the age and gender between GERD group and comparative group,but statistically significant differences existed among the nationality,BMI index and smoking proportion.Prevalence of periodontal disease was higher in the GERD group than the comparative group,the severity of periodontal disease kept increasing rate in the GERD group than the control group,Logistic regression analysis indicated that the age was the risk factor of periodontitis,the not smoking and not GERD was the protect factor for periodontitis.Conclusion The GERD disease is one of the risk factor of periodontitis.