吸入性肺炎相关生物学标记物的研究进展

Research progress on biomarkers in the diagnosis of aspiration pneumonia

口咽及胃内容物的反流、误吸可导致化学性、阻塞性和(或)感染性肺炎的发生,以上统称为吸入性肺炎。吸入性肺炎在临床上具有较高的发病率和病死率,但由于缺乏典型临床表现及特异性标记物,对于吸入性肺炎的诊断及不同类型的区分仍较困难。pH值监测及胃蛋白酶是目前常用的两种检测指标,α-淀粉酶、可溶性髓样细胞触发受体-1及呼出气冷凝液中白细胞三烯等具有良好的研究、应用前景。

The reflux and aspiration of oropharyngeal and gastric contents can lead to chemical,obstructive,infectious pneumonia,the above are collectively referred as aspiration pneumonia,which in clinic with high morbidity and mortality.Recognizing and managing the different types of aspiration events remain a challenging task due to the lack of distinguishing clinical or laboratory characteristics.pH monitoring and pepsin are now commonly used detection index,α-amylase,soluble triggering receptor expressed on myeloid cells 1 and leukotrienes in the breath condensate have a good research and application prospect.