MicroRNA、Toll样受体与HIV发病机制慢性免疫激活的研究进展

Research advances of the relationship among microRNA/Toll-like receptors and HIV-associated chronic immune activation

获得性免疫缺陷综合征(AIDS)是由人类免疫缺陷病毒(HIV)感染所致的致命性疾病。该病毒侵犯并摧毁宿主的免疫系统,初始感染CD4^+T细胞,逐渐呈现出慢性免疫激活的状态并最终导致AIDS的发生。MicroRNAs(miRNA),小型非编码RNA,在控制HIV病毒的感染及复制过程中发挥着重要的作用。Toll样受体(TLRs)在病原体诱导的免疫激活现象中起决定性的作用。本综述阐述了miRNA与HIV病毒间的相关联系,并介绍miRNA在AIDS发病机制慢性免疫激活的作用及其与TLRs的关系。

Acquired immunodeficiency syndrome(AIDS) is a fatal illness caused by a retrovirus known as the human immunodeficiency virus(HIV).The viruses break down the body's immune system,infect CD4^+ T cells initially,exhibit a state of chronic immune activation gradually and lead to AIDS progressively.Micro RNAs(mi RNAs),small non-coding RNAs,play crucial roles in controlling HIV-1 infection and replications.Toll-like receptors(TLRs) could play a central role in pathogen induced immune activation.In this review,we summarized the relationship between mi RNA and HIV.Furthermore,we explore the role of mi RNA and TLRs in the chronic immune activation.