维生素D与自身免疫性甲状腺疾病的研究进展

Research progress of vitamin D and autoimmune thyroid disease

自身免疫性甲状腺疾病(AITD)是一种T淋巴细胞介导的器官特异性自身免疫性疾病,主要包括桥本甲状腺炎(HT)和Grave病(GD),其发病机制尚不明确,可能与遗传、环境及免疫等有关。维生素D除具有调节骨和钙磷代谢,防治骨质疏松外,近年研究发现维生素D可能通过影响T淋巴细胞的增殖与分化,参与免疫调节,维持免疫内稳态。本文综述维生素D与AITD相关性的研究进展,旨在为AITD的预防与治疗提供新的思路。

Autoimmune thyroid disease(AITD) is a kind of organ specific autoimmune disease mediated by T lymphocytes cell,most including Hashimoto thyroiditis(HT) and Grave disease(GD).Its pathogenesis is still unclear,being related to genetic,environmental and immune etc.Vitamin D(VD) can adjust metabolism of bone,calcium and phosphorus,preventing and treating osteoporosis.Some studies in recent years found that VD also plays a important role of immune regulation and immunologic homeostasis by affecting proliferation and differentiation of T lymphocytes.This article reviewed in the relationship between VD and AITD,in order to provide a new way of thinking for the prevention and treatment of AITD.