细胞凋亡抑制蛋白-1在宫颈癌及宫颈癌化疗耐药方面的研究进展

Research progress of c-IAP1 in cervical cancer and chemotherapy resistance

细胞凋亡抑制蛋白-1(c-IAP1)属于凋亡抑制蛋白家族(IAPs),是一种重要的细胞内凋亡调节蛋白,通过抑制caspase酶活性以及参与调节核转录因子κB(NF-κB)信号通路抑制细胞凋亡并促进细胞存活,进而参与肿瘤形成及化疗耐药,亦可通过调节Rho家族(Ras homologue)中Ras相关的C3肉毒素底物1(Rac1)等的活性,在肿瘤的转移中发挥重要作用。研究表明,c-IAP1在宫颈癌的发生发展、治疗及预后判断方面均发挥重要作用,现就其在宫颈癌及宫颈癌化疗耐药方面的研究进展作一简要概述。

Cellular inhibitor of apoptosis protein 1(c-IAP1),a member of apoptosis inhibitory protein family,is an important intracellular apoptosis regulatory protein,which inhibits apoptosis and promotes cell survival by inhibiting the activity of caspase and participating in the regulation of NF-κB signaling pathway,and then participates in the formation of tumor and chemotherapy drug resistance,it can also play an important role in the metastasis of tumors by regulating the activity of Rac1 in the Rho family.Studies have indicated that c-IAP1 plays an important role in the occurrence,development,treatment and prognosis of cervical cancer,this paper gave a brief overview of their progress on cervical cancer and resistance to chemotherapy in cervical cancer.