远程缺血预处理预防对比剂肾病的研究进展

Development of prevention of remote ischemic preconditioning on contrast-induced nephropathy

随着对比剂广泛应用于临床诊断及介入治疗,对比剂肾病(CIN)已成为医院获得性急性肾损害的主要原因。除水化外,目前还尚无其他预防CIN发生的有效措施,为此,进一步探索减少CIN发生的新方法具有重要的意义。而远程缺血预处理是机体对抗缺血-再灌注损伤有效的内源性保护机制,其不仅对心脏起保护作用,对其他器官也具有普遍的保护作用。本文针对这一特点,对远程缺血预处理预防CIN的作用原理、CIN的发展机制等内容进行综述。

As contrast agents are widely utilized in clinical diagnostic and interventional procedures,contrast induced nephropathy(CIN) has become one of the leading causes of hospital-acquired acute kidney injury(AKI).At present,there is still no effective prophylactic regimen available to prevent occurrence of CIN except hydration.Therefore,it is necessary to develop novel strategies to decrease CIN incidence.Remote ischemic preconditioning(RIPC) is defined as an effective endogenous protective mechanism against ischemia reperfusion(I/R) injury,which not only protects the heart,but also protects other organs.According to this characteristics,this paper summarized the mechanism of function of RIPC to prevent CIN and CIN development mechanism,etc.