维生素D与老年衰弱综合征的关系

Relationship between vitamin D and frailty syndrome

维生素D是一种类固醇类衍生物,在人体钙磷代谢、神经系统、免疫、肌肉及内分泌中扮演着重要角色。然而,维生素D缺乏在世界范围内流行,越来越多的研究表明维生素D缺乏与衰弱有密切关系,衰弱人群血清25-羟维生素D[25-(OH)D]水平明显低于健康人群。此外,目前已证实补充维生素D可改善患者肌肉功能、身体活动能力等,而肌肉功能及身体活动能力可直接影响衰弱表型。本文就维生素D与老年衰弱综合征之间的关系、可能的相关机制及维生素D的补充对老年衰弱综合征的影响进行阐述,从而加强临床医师对两者关系的认识,并为临床研究提供依据。

Vitamin D,as a steroidal derivative,plays an important role in calcium and phosphorus metabolism,nerve system,immune system,muscular system,and endocrine system.Vitamin D deficiency is a world wide health problem,more and more studies demonstrated that vitamin D deficiency is related to frailty.Serum 25-(OH)D levels are lower in the frail subgroup when compared with robust one.In addition,it has been identified that vitamin D supplementation can improve muscle function and physical performance which effects frailty phenotype directly.The paper reviewed the relationship between vitamin D and frailty especially underlying mechanism and effect of vitamin D supplementation on frailty,and to enhance clinicians' understanding of the relationship and provide reference for clinical study.