调节性B细胞对系统性红斑狼疮CD4^+ T细胞亚群的影响

Effects of regulatory B cells on CD4^+ T cell subsets in systemic lupus erythematosus

系统性红斑狼疮(SLE)是一种发病机制复杂的自身免疫性疾病。许多研究证实,SLE患者外周血中存在CD4^+T细胞亚群的失衡。因此治疗SLE的关键是纠正紊乱的CD4^+T细胞亚群,恢复免疫稳态。目前有研究发现调节性B细胞(Breg)对CD4^+T细胞亚群的分化有一定的调控作用。这提示分析Breg细胞调节CD4^+T细胞亚群的机制,有助于为SLE疾病的治疗提供新思路。

The pathogenesis of systemic lupus erythematosus(SLE) is complexity. Many studies have confirmed that there existed the CD4^+ T cell subsets disorders in peripheral blood of patients with SLE. Therefore, to correct the abnormity of CD4^+ T cell subsets and to restore the immune homeostasis are the key to the treatment of the SLE. At present, it is found that regulatory B(Breg) cells have a certain effect on the differentiation of CD4^+ T cell subsets. This promptes that analysis of the mechanism of Breg cells regulating the differentiation of CD4^+ T cell subsets is helpful to provide a new way for the treatment of SLE.