鞘糖脂对破骨细胞、成骨细胞形成及溶骨性骨病的影响

Effect of glycosphingolipids on osteoclastogenesis, osteoblastogenesis and osteolytic bone diseases

鞘糖脂位于细胞膜脂质双分子层,是构成哺乳动物细胞膜的必需成分之一,并且在不同组织,甚至同一细胞不同间期组成成分是不同的;其生物学功能非常复杂。很多研究发现组织器官中鞘糖脂的异常分泌与各类疾病具有显著的相关性,因此鞘糖脂已成为近年来研究的热点问题。最近研究表明鞘糖脂在破骨细胞、成骨细胞形成过程中以及多溶骨性骨病的发生发展及治疗过程中都具有至关重要的作用。本文将对鞘糖脂在破骨细胞、成骨细胞形成过程中的作用机制以及溶骨性骨病的发生发展及治疗过程中的作用机制作一综述。

Glycosphingolipids locate in the bilayer lipid membrane. They are important compositions of the membrane of mammals and are characterized by heterogenic composition among tissues and even in the same cell during different states of development. Their biological function is very complex. The abnormal expressions of glycosphingolipids in various tissues often have obvious associations with diverse diseases. Therefore, glycosphingolipids have become hot issues in recent years. And the up-to-date studies have shown that glycosphingolipids play an crucial role in the development of osteoclastogenesis, osteoblastogenesis and osteolytic bone diseases. In this paper, the role of glycosphingolipids in the process of osteoclast formation and osteoblast formation, as well as the development of osteolytic bone disease and the mechanism of action in the process of treatment were reviewed.