降脂药联合血管紧张素Ⅱ受体拮抗剂对波动性高糖诱导心肌细胞凋亡的影响

Effects of lipid lowering drugs combined with angiotensin receptor blocker on myocardial apoptosis induced by volatility high glucose

冠心病是我国发病率最高的疾病之一,对于冠心病的治疗及预后是临床的重要问题,当冠心病合并糖尿病时,增加了高血糖对心血管系统的损伤,尤其是未使用降糖药治疗以及血糖控制不好的冠心病患者,体内波动的血糖水平会对心肌细胞有更大的损伤。阿托伐他汀钙及替米沙坦在临床上的单独使用对冠心病合并糖尿病都是有用的,但是二者联合应用后的效益是仍需研究探索,这对评估临床上联合用药的指征具有非常大的价值。

Coronary heart disease(CHD) is one of the highest incidence of diseases in our country, for the treatment and prognosis of CHD is one of the important problems. CHD combined diabetes mellitus can increase the blood sugar damage to the cardiovascular system, especially in patients unused medications treatments and poor blood glucose control, fluctuations in blood sugar levels in the body has the greater damage to the myocardial cells. Atorvastatin calcium and telmisartan in clinical used alone is useful for CHD combined diabetes mellitus, but the benefit of join application of the two drugs need to be explored, which is of great value in assessing clinical indications for combination therapy.