间充质干细胞在脓毒症治疗中的研究进展

Advances in treatment of sepsis using mesenchymal stem cells

脓毒症(Sepsis)是一种威胁生命的综合征。宿主对微生物感染的免疫应答至关重要,脓毒症早期以过度炎症反应为主,而脓毒症晚期通常伴有免疫抑制。干细胞是一种有前景的脓毒症治疗手段。本文总结了干细胞在脓毒症中的作用机制,重点探讨间充质干细胞这种细胞目前表现出最广阔的治疗前景。

Sepsis is a life-threatening syndrome.The host immune response to microbial infection is critical,with early-phase sepsis characterized by a hyperinflammatory immune response,whereas the later phase of sepsis is often complicated by immunosuppression.Stem cells constitute promising therapeutic agents for sepsis.We examine the rationale for stem cells in the treatment of sepsis,focusing on mesenchymal stem/stromal cells,which currently demonstrate the greatest therapeutic promise.