狼疮性肾炎诊断和治疗的研究进展

Diagnosis and treatment of lupus nephritis: current paradigms and emerging strategies

近年来狼疮性肾炎在病理生理学研究方面取得的进展,提高了疾病的诊断水平和治疗疗效。作用于狼疮性肾炎免疫学发病机制通路上不同靶点的新型药物,尤其是B细胞耗竭药物和多靶点治疗方案是目前研究的热点,未来希望能够通过有效的个体化治疗改善狼疮性肾炎患者的远期预后。

Significant progress has been made on unraveling the pathogenesis of lupus nephritis,and how to diagnose and treat the disease.Despite disappointing results of several recent trials,novel therapies targeting diverse immunologic pathways are being actively studied in lupus nephritis.Two promising strategies include the use of B-cell depletion therapy and multitarget therapy with calcineurin inhibitors.The ultimate goal of these efforts is to treat the patients in a more strategic,personalized manner that improves long-term outcomes.