缺血性卒中对不宁腿综合征发病率的影响

EFFECTS OF ISCHEMIC STROKE ON THE PREVALENCE OF RESTLESS LEGS SYNDROME

目的探讨缺血性卒中对不宁腿综合征(RLS)发病率的影响及梗死部位与RLS之间的关系。方法选取2014年1—7月在该院神经内科就诊无RLS病史的172例卒中患者[平均年龄(67.38±7.56)岁]作为卒中组研究对象,通过影像学检查明确梗死部位。选取同期在该院体检中心体检的196名健康者[平均年龄(66.73±5.72)岁]作为对照组研究对象。通过一年的随访,比较二组研究对象RLS发病率及不同梗死部位对RLS发病率的影响。结果卒中组RLS发病率较对照组显著升高(P<0.05),相对危险度(RR)为4.56,95%的可信区间为3.966~5.249。基底节区梗死患者RLS发病例数与发病率均显著高于其他梗死部位(P<0.05)。结论缺血性卒中可显著增加RLS的发病风险,基底节区梗死是缺血性卒中引发RLS的关键因素。

Objective To investigate the effects of ischemic stroke on the prevalence of restless legs syndrome(RLS)and the relationship between infarct locations and RLS.Methods Chose one hundred and seventy-three patients(average age 67.38±7.56)with ischemic stroke and without RLS as ischemic stroke group who were diagnosed by department of neurology,the affiliated hospital of Qingdao university from January 2014 to July 2014,and recorded every patients' infarct location by CT and MRI test.Another one hundred and ninety-six healthy people(average age 66.73±5.72)who were tested by health examination center of same hospital during same time as control group.With a one-year follow-up,compared morbidities between the two groups and analyzed the relationship between infarct locations and RLS.Results The contrast between ischemic stroke group and control group suggested that RLS prevalence of ischemic stroke group was significantly increased(P<0.05),relative risk was 4.56,95%confidence interval 3.966~5.249.RLS prevalence of patients with basal ganglia infarction was significantly higher than other infarct locations(P<0.05).Conclusion Ischemic stroke can significantly increase the risk of RLS.Basal ganglia infarction is an important pathogenic factor.