COX-2选择性抑制剂在骨关节炎中作用的研究进展

ADVANCES IN RESEARCH ON THE ROLE OF COX-2 SELECTIVE INHIBITORS IN OSTEOARTHRITIS

目的骨关节炎(OA)是人类中最常见的关节炎类型,常伴有软骨缺损、滑膜炎、软骨下骨硬化等相关改变。OA治疗通常涉及使用非甾体抗炎药(NSAID),这是首选的药物治疗方法。然而,NSAID经常伴有副作用出现。环氧合酶(COX)-2选择性抑制剂,例如塞来昔布,已经成功地用作OA治疗的替代物,并且已证明其副作用较少。我们对近期发表的文献进行了查阅,研究总结了塞来昔布对OA患者软骨、滑膜和骨骼的影响,尤其是疾病改善作用。研究结果表明,塞来昔布的疾病改善作用似乎是通过调节前列腺素、细胞因子和组织的直接变化来介导的。所以本综述对COX-2选择性抑制剂在OA中的作用进行系统阐述,以求对COX-2选择性抑制剂的疾病改善作用有更一步的认识。

Objective Osteoarthritis(OA)is the most common type of arthritis in humans,and it is often associated with cartilage defects,synovitis,and subchondral bone sclerosis.OA treatment usually involves the use of non-steroidal anti-inflammatory drugs(NSAIDs),which is the preferred medical treatment.However,NSAIDs are often accompanied by side effects.Cyclooxygenase(COX)-2 selective inhibitors,such as celecoxib,have been successfully used as an alternative to OA treatment and have been shown to have fewer side effects.We reviewed the recently published literature and summarized the effects of celecoxib on cartilage,synovium and bone in OA patients,especially disease improvement.Our results suggested that the disease-improving effected celecoxib appear to be mediated through modulation of direct changes in prostaglandins,cytokines and tissues.Therefore,this review systematically describes the role of COX-2 selective inhibitors in OA in order to gain a further understanding of the disease-improving effects of COX-2 selective inhibitors.