摘要
细胞色素P450是一类广泛分布于生物体内的重要酶系,能够代谢多种内源性和外源性物质,在昆虫对杀虫剂代谢解毒方面起着重要作用。P450介导的杀虫剂代谢解毒作用具有普遍性和交互抗性的特点,其机制涉及酶表达量增加和酶活性改变。该文以蚊虫为例综述了P450介导的抗药性一些新进展。
Cytochrome P450 is an important family of enzymes ubiquitously expressed in organisms.It can metabolize a variety of endogenous and exogenous substances,and plays an important role in the metabolism and detoxification of insecticides in insects.The metabolism and detoxification of insecticides mediated by P450 are characterized by universality and cross resistance,and the mechanisms involve an increase in enzyme expression and a change in enzyme activity.This article reviews some new research advances in the P450-mediated insecticide resistance of mosquitoes.
作者
王洋
宋晓
程鹏
公茂庆
WANG Yang;SONG Xiao;CHENG Peng;GONG Mao-qing(School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan250062,Shandong Province,China;Shandong Institute of Parasitic Diseases,Shandong First MedicalUniversity&Shandong Academy of Medical Sciences)
出处
《中国媒介生物学及控制杂志》
CAS
2019年第5期589-592,共4页
Chinese Journal of Vector Biology and Control
基金
国家自然科学基金(81672059,81871685)
山东省重点研发计划(2018GSF118040,2019GSF111006)
山东省医学科学院医药卫生科技创新工程~~
关键词
蚊虫
细胞色素P450
抗药性
分子机制
Mosquitoes
Cytochrome P450
Insecticide resistance
Molecular mechanism
