趋化因子CXCL13与系统性红斑狼疮的研究进展

Research progress of chemokine CXCL13 in systemic lupus erythematosus

系统性斑狼疮(SLE)是自身免疫性疾病的原型,由于机体的免疫功能紊乱而产生多种自身抗体,造成多个系统和器官的损伤,而出现多样化的临床表现。其发病机制极为复杂,近年来趋化因子在自身免疫性疾病中的作用越来越受到关注。CXCL趋化因子配体13(CXCL13)属于CXC趋化因子家族,主要由次级淋巴器官中的树突状细胞和巨噬细胞产生,研究表明其与SLE多个系统受累有关,本文就趋化因子CXCL13在SLE发病中的作用作一综述。

Systemic lupus erythematosus is the prototype of autoimmune disease.Because of the disorder of immune function,it produces a variety of autoantibodies,resulting in multiple system,organ damage and a variety of clinical manifestations.Its pathogenesis is extremely complexed,while the role of chemokines in autoimmune diseases has attracted more and more attention in recent years.CXC chemokine ligand 13(CXCL13)belongs to the CXC chemokine family and is mainly produced by dendritic cells and macrophages in the secondary lymphoid organs.Studies have shown that it is related to the multiple systems involvement of SLE,this article reviews the role of CXCL13 in the pathogenesis of SLE.