蒙药材干达嘎日木(悬钩子木和接骨木)解热镇痛抗炎作用的实验研究

An Experimental Study on Antipyretic,Analgesic and Anti-inflammatory Effects of Mongolian Medicine Rubus Sachalinesis Leveille

目的:研究蒙药材悬钩子木和接骨木的解热镇痛抗炎作用;并对比两种药材的药理作用。方法:采用干酵母致大鼠发热法,小鼠热板法,大鼠压痛甩尾法,二甲苯致小鼠耳肿胀法考察二药解热、镇痛及抗炎作用。结果:悬钩子木和接骨木水提取物具有显著的抑制干酵母致大鼠发热反应(P<0.01)、提高小鼠对热板及大鼠对压力所致的痛阈值(P<0.05或P<0.01)、减少二甲苯致小鼠耳肿胀率(P<0.05或P<0.01)。结论:蒙药材悬钩子木和接骨木的水提取物对实验小鼠、大鼠具有良好的解热,镇痛,抗炎等药理作用;两种药材之间、生品及炮制品之间的解热,镇痛,抗炎作用无明显差异。

Objective: To study antipyretic,analgesic and anti-inflammatory effects of ramulus rubi and elderberry,and compare their pharmacological actions. Methods: The test was performed by fever rat model induced by dried yeast,hot plate in mice,tail flick for rates,and ear swell of mice induced by dimethyl benzene. Results: ramulus rubi and elderberry could significantly inhibit the fever reaction of mice,improve the pain thresholds of mice to hot plate and the pain threshold of rats to pressure,and reduce swelling rate of mice induced by dimethylbenzene. Conclusion: Ramulus rubi and elderberry have good antipyretic,analgesic and anti-inflammatory effects on mice and rats,and the effects are same between the two medicines and between crude drug and processing medicine.