蒙药巴日巴德-10对NAFLD模型大鼠的治疗作用

The effects of Baru bade- 10 in the treatment of NAFLD in rats moder

非酒精性脂肪性肝病(NAFLD)的发病及早期诊断率逐年攀升,发病年轻化,已成为全球性公共卫生问题。在蒙医学整体观和辩证法理论指导下,根据"赫依(气)-希拉(热)-巴达干(寒)"理论对NAFLD应用独特"三根调节法"(抑"赫依"、清"希拉"、祛"巴达干")进行治疗,疗效确切;并据此提出"三根失调"导致脂代谢异常,而过氧化物酶体增殖物激活受体(PPARs)及肝X受体(LXR)α可能在其中扮演关键角色"的假说。本研究选择了治疗NAFLD的代表性蒙药巴日巴德-10,用大鼠NAFLD模型,以PPARs及LXRα为切入点,结合免疫组化、Western blot和RT-PCR等技术。蒙药巴日巴德-10治疗NAFLD的作用可能与降血脂、改善肝功能、抗氧化作用以及改善胰岛素抵抗有关。

Morbidity and the early diagnostic rate of NAFLD is rising year after year,which has become a global public health problem. under the guidance of overall concept of Mongolian medicine and dialectics theory,and according to ' hei'( gas)- ' shar'( hot)- ' badgan'( cold) theory of NAFLD application unique ' three pillars adjustment method treatment,It is the exact effect. It puts forward the hypothesis that ' ' cause lipid metabolism disorders,and peroxisome proliferation content activation receptor( PPARs) and hepatic X receptor( LXRa) alpha may be in for a key role' This study choose a representative prescription,which is decoction of BARIBADE- 10; establish NAFLD model of rats; take PPARs and LXRa as the Breakthrough Point; combine immunohistochemical method、Western blot and RT- PCR technology. We try to shows the effects of ' three pillars disorder'on PPARs and LXRa at the general and cellular level. Provided a new idea and method to treat NAFLD by Mongolian medicine.