(2R,3R)-2,3-二甲氧基-1,1,4,4-四苯基-1,4-丁二醇的一种实用制备方法（英文）

A practical approach to (2R,3R)-2,3-dimethoxy-1,1,4,4-tetraphenyl-1,4-diol

基于(2R,3R)-1,1,4,4-四苯基丁四醇的区域选择性2,3-二甲基化反应,建立了一种制备C_2手性二醇即(2R,3R)-2,3-二甲氧基-1,1,4,4-四苯基-1,4-丁二醇的实用方法.结果表明:与文献相比,该合成避免了酸的使用,减少了多取代THF衍生物的生成,提高了产率,不仅是制备(2R,3R)-2,3-二甲氧基-1,1,4,4-四苯基-1,4-丁二醇的便捷方法,也为(2R,3R)-1,1,4,4-四取代丁四醇的区域选择性衍生化提供了重要信息.

A practical approach to(2R,3R)-2,3-dimethoxy-1,1,4,4-tetraphenylbutane-1,4-diol,a C2 chiral diol,was developed based on highly regioselective 2,3-methylation of(2R,3R)-1,1,4,4-tetraphenylbutaneol with MeI/NaH. The results indicated that compared with the literature,this procedure avoided the treatment with acid,reduced the generation of poly-substituted THF derivative,and increased the yield. This report not only provided a practical approach to prepare(2R,3R)-2,3-dimethoxy-1,1,4,4-tetraphenylbutane-1,4-diol,but also presented a significant reference for the regioselective derivatization of(2R,3R)-1,1,4,4-tetra-substituted butanetetraols.