急性一氧化碳中毒后迟发性脑病患者神经元特异性烯醇化酶的变化及意义

Changes of neuron-specific enolase and its significance in delayed encephalopathy after acute carbon monoxide poisoning

目的 探讨急性一氧化碳中毒后迟发性脑病 (DEACMP)患者是否合并脑神经元的损伤。方法 4 5例DEACMP患者按病情轻重分为 3组 ,应用酶联免疫分析法测定患者血清神经元特异性烯醇化酶 (NSE)浓度并和对照组 ( 2 0例 )比较。应用单因素方差分析方法分析NSE浓度与病情严重程度以及预后的关系。结果 对照组血清NSE浓度为 ( 7.2± 1.6 ) μg/L。轻中重度DEACMP患者血清NSE浓度分别为 ( 10 .7± 2 .1) μg/L ,( 12 .9± 2 .5 ) μg/L ,( 17.9± 3.9) μg/L ,与对照组比较均有显著性差异 (P均 <0 .0 5 )。结论 DEACMP患者血清NSE浓度明显增高 ,NSE浓度不仅可作为脑神经元损伤的量化指标 ,而且也是判断病情、估计预后的重要参数。

Objective It is to explore whether delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) in patients accompany with neuronal damage. Methods Forty five patients with DEACMP were divided into slight, moderate and severe groups according to their condition. The serum neuron-specific enolase (NSE) levels in them were determined with ELISA and compared with that in 20 healthy individuals. The relations were analyzed among NSE concentration and the extent of the neurologic damage and prognosis. Results The concentration of serum NSE in control group was (7.2±1.6)μg/L. That in slight group, moderate group and severe group were (10.7±2.1)μg/L, (12.9±2.5)μg/L and (17.9±3 9)μg/L respectively. And there were significant differences between those and NSE in control group (all P <0.05). Conclusion The levels of the serum NSE in the patients with DEACMP have a remarkably increase. The concentration of NSE not only provides quantitative information about the degree of certain neurologic lesions, but also possibly serves as an important parameter of judging the condition assessing the prognosis.