氧化剂存在下吡啶叶立德与1,4,4a,8a-四氢-1,4-桥亚甲基萘-5,8-二酮的反应

Reaction Between Pyridinium N-Ylides and 1,4,4a,8a-Tetrahydro-1,4- methanonaphthalene-5,8-dione in the Presence of Oxidant

在 [( Py) 4Co( HCr O4 ) 2 ]存在下 ,吡啶叶立德、喹啉叶立德或异喹啉叶立德分别和 1 ,4,4a,8a-四氢 -1 ,4-桥亚甲基萘 -5 ,8-二酮反应 ,一步法合成了中氮茚类多环化合物 ( 1 a～ 1 c,2 a～ 2 b,3 ) .该方法原料易得 ,反应条件容易控制 。

Some tricyclic indolizine compounds having sPLA_2 inhibitory activities have been reported. A general method for preparing multi-cyclic indolizine compounds(1a—1c, 2a—2b and 3) in moderate yields(45%—71%) by a 1,3-dipolar cycloaddition reaction of pyridinium N-ylides, isoquinolinium N-ylides or quinolinium N-ylides to 1,4,4a,8a-tetrahydro-1,4-methanonaphthalene-5,8-dione, followed by an aromatization, in the presence of tetrakispyridine cobalt(Ⅱ) dichromate(TPCD) is described. The method features cheap reagents ,simple workup procedure. The above compounds(1a—1c, 2a—2b and 3) are of great value for evolution in medicinal research studies.