HMBA单独或与HMBPA联合作用对MELDS19细胞生长及分化影响的研究

On the Effects of HMBA and HMBPA on MELDS19 Cell Growth and Differentiation

目的 研究HMBA单独或与HMBPA联合作用对MELDSl9细胞的抑制及诱导分化作用．方法 绘制HMBA单独或与HMBPA联合下的MELDS19细胞生长曲线，联苯胺染色法检测其分化百分率，成集落实验检测细胞增殖情况．结果 MELDS19细胞在HMBA与HMBPA联合作用下增殖能力下降，联苯胺染色阳性率增高．结论 HMBA与HMBPA联合作用能增强抑制MELDS19细胞的生长繁殖及诱导其分化能力。

Objective To investigate the effects of HMBA and HMBPA on MELDS19 cell growth and differentiation.Methods To draw the MELDS19 cell growth curve, count the MELDS19 cell mitosis index,colony forming test and benziding staining positivity percentage when MELDS19 cell is exposed to HMBA and HMBPA.Results The number of MELDS19 cell reduces, mitosis index and colony forming decrease. Benzidine staining positivity increase.Conclusion HMBA and HMBPA can inhibit MELDS19 cell proliferation and induce differentiation.