急性心肌梗死与柯萨奇B组病毒感染关系的研究

Study on the relationship between the infection of Coxsackie B virus and acute myocardial infarction

目的 探讨柯萨奇B组病毒感染与急性心肌梗死 (AMI)的发病关系。方法 应用SPA吸收IgG结合间接ELISA法检测AMI患者血清中柯萨奇B组病毒特异性IgM抗体及中和抗体。结果 4 8例AMI患者血清特异性IgM抗体阳性率为 75 % ,血清中和抗体阳性率为 85 4 % ,与正常对照组相比差异非常显著。双份血清试验 ,恢复期血清抗体效价高于初期血清抗体效价 4倍以上。结论 AMI发病与柯萨奇B组病毒感染有关。

Objective To explore the relationship between the infection of Coxsackie B virus and the occurrence of acute myocardial infarction(AMI). Methods Staphylococcal protein A(SPA)'s absorbing IgG and enzyme-linked immunosorbent assay (ELISA) were performed to detect both Coxsackie B virus-specific IgM antibody and neutralizing antibody.Results Positive rate of specific IgM antibody and neutralizing antibody was 75% and 85.4%respectively in the sera of 48 AMI patients .Conclusion There was significant difference between AMI group and normal control group in detecting the Coxsackie B virus-specific IgM antibody and neutralizing antibody.In double sera experiments the antibody titer in convalescent period was 4 times more than that in early days.We concluded that the occurrence of AMI was related to the infection of Coxsackie B virus.