微小病毒B19宫内感染与早产儿、足月小于胎龄儿的相关研究

Relationship between human parvovirus B19 intrauterine infection and premature infant and full term small gestational age

目的 观察人类微小病毒B19(HPVB19)宫内感染与早产儿、足月小于胎龄儿的关系。方法 采用ELISA方法对 35例早产儿、30例足月小于胎龄儿进行了血清HPVB19 IgM及IgG的检测 ,并将 4 8例正常新生儿脐血作为对照组。结果 35例早产儿中HPVB19 IgM阳性率为 2 8 5 7% (10 /35 ) ,30例足月小于胎龄儿组HPVB19 IgM阳性率为 2 3 33% (7/30 ) ,4 8例正常对照组中HPVB19 IgM阳性率为 4 17% (2 /48)。两组与正常对照组比较 ,差异有非常显著性意义 [χ2 =7 87,P <0 0 1,相对危险度 (RR) =6 84 ;χ2 =4 90 ,P <0 0 5RR =5 6 ]。结论 微小病毒B19宫内感染与早产的发生、胎儿宫内生长迟缓相关。

Objective To observe the relation between human parvovirus B19 (HPVB19) intrauterine infection and occurrence of premature infant and full term for newborns small gestational age.Methods The level of serum HPVB19-IgM was measured by ELISA in 35 premature infants and 30 full term for neonates for small gestational age and compared to that of 48 normal newborn infants.Results The positive rate of serum HPVB19-IgM was 28.57%(10/35) in premature infant group, 23.33%(7/30) in full term small gestational age group,4.17%(2/48) in normal group,and significantly different in premature infant group and full small gestational age group and normal group (χ 2=7.87,P<0.01,RR=6.84 and χ 2=4.9,P<0.05 RR=5.6).Conclusion HPVB19 intrauterine infection is related with the occurrence of premature and retardation of intrauterine growth.