钠-葡萄糖共转运蛋白2抑制剂对糖尿病肾病的保护作用

Protection of sodium glucose cotransporter-2 inhibitors on diabetic nephropathy

钠-葡萄糖共转运蛋白2(sodium-glucose cotransporters-2,SGLT2)抑制剂是一种新型的降糖药物。目前有研究表明SGLT2抑制剂除有效降低血糖外,对糖尿病肾病可能有保护作用,主要表现在减少尿蛋白、降低血尿酸、改善肾脏组织学及形态学的病理学改变等,可能与抗氧化、抗炎、抗纤维化,改善肾脏的高滤过,降血压等机制有关。

Sodium-glucose cotransporter-2(SGLT2)inhibitors have been developed as a novel antihyperglycaemic agent. The current studies have shown that SGLT2 inhibitors can effectively lower blood glucose. In addition,SGLT2 inhibitor may play a role in the protection of the diabetic nephropathy,mainly to reduce urinary protein,lower blood uric acid,improve renal histological and morphological pathology,etc. The mechanism may be associated with its anti-oxidant,anti-inflammatory,anti-fibrotic effects,renal hyperfiltration improvement,blood pressure reduce,etc.