摘要
目的 探讨复方决明提取物抗高血压的作用机制。方法 放射免疫分析法测定自发性高血压大鼠 (SHR)血浆中血管紧张素 (ANG )和肾素活性 (RA)、内皮素 (ET)、心钠素 (ANP)、醛固酮 (AL D)等血压相关物质的含量 ,利尿实验测定尿量。结果 不同剂量的复方决明提取物均能降低 SHR大鼠血浆的 ANG 含量和 RA,但对 AL D,ET,ANP及尿量均无影响。结论 复方决明提取物的降压作用与降低肾素 -血管紧张素有关 ,而与 AL D,ET。
Object To probe into the antihypertension activity mechanism of extracts from Compound Jueming (CJ). Methods The method of radioimmunoassay was used to assay the concentration of the related substances on spontaneously hypertensive rats (SHR) such as angiotensin Ⅱ (ANGⅡ), renin activity (RA), endothelin (ET), atrial natriuretic polypeptide (ANP), aldosterone (ALD), and urine. Results All of the three doses (9.5, 7.2, and 4.8 g/kg) of extracts from CJ reduced ANG Ⅱ and RA, but had no influence on ALD, ET, ANP, and urine in SHR. Conclusion The antihypertension effect of extracts from CJ is related to decreasing of renin angiotensin, but not to ALD, ET, ANP, and urine.
出处
《中草药》
CAS
CSCD
北大核心
2004年第2期180-182,共3页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目 ( 3 9470 860 )
关键词
复方决明提取物
高血压
血管紧张素Ⅱ
肾素活性
醛固酮
心钠素
内皮素
extracts from Compound Jueming (CJ)
hypertension
angiotensin Ⅱ (ANG Ⅱ)
renin activity (RA)
aldosterone (ALD)
atrial natriuretic polypeptide (ANP)
endothelin (ET)
