变容体系中卡那霉素生物合成动力学模型参数灵敏度分析

Sensibility analysis of parameters in kinetic model of Kanamycin biosynthesis in volume-varied system

在变容体系中卡那霉素发酵过程动力学研究的基础上,构建了过程动力学模型,并对10个模型参数进行了估计,各估计值均符合其物理意义,且模型与实验结果相吻合.对各参数进行了灵敏度分析,指出各参数对状态变量的灵敏度.

Based on the metabolism characteristics of Streptomyces kanamyceticus, a kinetic model describing the volume-varied Kanamycin fermentation process was established. The values of the parameters in this model were estimated by executing the programming function integrated in Microsoft Excel XP. The sensibilities upon status variables of these parameters were also analyzed.