克拉霉素的示波极谱测定及其电化学行为

Determination of clarithromycin by single-sweep oscillopolarography and its electrochemical behavior

在 0 .0 5mol LNaOH(pH 1 2 .7)介质中 ,克拉霉素在滴汞电极上产生一灵敏的还原峰 ,峰电位Ep=- 1 .35V(vs.SCE)。其一阶导数峰电流ip′与克拉霉素浓度在 8.0× 1 0 -6～ 4.8× 1 0 -5mol L范围内有良好的线性关系 (r=0 .9991 ) ,检出限为 4 .0× 1 0 -6mol L。此法已用于片剂的测定。用线性扫描和循环伏安法研究了体系性质 ,结果表明 。

In a medium of 0.05 mol/L NaOH, a sensitive reduction wave of clarithromycin was obtained by single-sweep oscillopolarography. The peak potential was at -1.35 V(vs.SCE). The linear range between the peak current and the concentration of clarithromycin was between 8.0×10^(-6)～4.8×10^(-5) mol/L with the detection limit of 4.0×10^(-6) mol/L. This method was used for determination of clarithromycin in tablets. The electrochemical behavior of the system was studied at HDME by linear sweep and cyclic voltammetry. The electrode reduction process of clarithromycin at DME was irreversible with adsorptive characteristics.