白蛋白微球经颈外动脉灌注后的体内分布及降解速度

The distribution and degradation of albumin microspheres injected into jugular external artery

目的 :探讨作为药物载体的白蛋白微球 (AMS)经颈外动脉灌注后在体内的分布及降解速度 ,以及栓塞血管再通时间 ,为AMS的安全性提供依据。方法 :经家兔颈外动脉灌注以12 5 I标记的平均粒径 56.3 μm的白蛋白微球后 ,测定局部组织及全身脏器内的放射剂量。用 760ml/L的泛影葡胺行家犬颈外动脉造影观察AMS灌注后末梢血管再通时间。结果 :微球经颈外动脉灌注后 92 .2 3 %集中于头颈局部组织内。微球对颈外动脉的微小分枝有明显的栓塞作用 ,栓塞的血管在 7～ 9d内再通。结论

Objective: To evaluate the distribution and degradatio n of albumin microspheres (AMS) with average diameter of 56.3 μm injected into jugular external artery.Methods: 125 I labeled AMS we re injected into rabbit's jugular external artery. The radioactive amount of loc al tissue and internal organs was measured. 760 ml/L urografin angiography was e mployed to observe the re opening of embolized vessels after AMS infusion of e xternal jugular artery in 5 dogs. Results: The AMS was mai nly concentrated in the target area (92.23%) after injection. The micro artery was obviously embolized by AMS and re opened in 7～9 days. Conclusio n : The AMS can be used as the drug bearer with delayed releasing eff ection.