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他汀类药物的抗血栓作用 被引量:35

Antithrombotic Effect of Statins
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出处 《医学临床研究》 CAS 2004年第1期12-14,共3页 Journal of Clinical Research
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参考文献14

  • 1Bonetti PO,Lerman LO,Napoli C,el a1.Statin effects beyond lipid lowering:are they clinically relevant[J]?Euro Heart J,2003,24:225-248.
  • 2Laufs U,Gertz K,Huang P,et al.Atorvastatin upregulates type Ⅲ nitric oxide synthase in thrombocytes,decreases platelet activation,and protects from cerebral ischemia in normocholesterolemic mice[J].Stroke,2000,31(10):2442-249.
  • 3Gertz K,Laufs U,Lindauer U,et al.Withdrawal of statin treatment abrogates stroke protection in mice[J].Stroke,2003,34:551-557.
  • 4Eto M,Kozai T,Cosentino F,et al.Statin prevents tissue factor expression in human endothelial cells:role of Rho/Rho-kinase and Akt pathways[J].Circulation,2002,105:1756-1759.
  • 5Rosenson RS.Brown AS.Statin use in acute coronary syndromes:cellular mechanism and clinical evidence[J].Curr Opin Lipidol,2002,13:625—630.
  • 6Son JW.Koh KK.Ahn JY,et al.Effects of statin on plaque stability and thrombogenicity in hypercholesterolemic patients with coronary artery disease[J].Int J Cardiol,2003,88(1):77—82.
  • 7Undas A, Brummel KE, Musial J, et al . Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V ,and factor Ⅻ and by enhancing factor V a inactivation[J]. Grculation ,2001,103(18) :2248-2253.
  • 8Musial J, Undas A, Undas R, et al . Treatment with simvastatin and low-dose aspirin depresses thrombin generation in patients with coronary heart disease and borderline-high cholesterol levels[J]. Thromb Haemost , 2001,85 : 221-225.
  • 9Morishita E, Minami S,Ishino C, et al . Atorvastatin reduces plasma levels of factor Ⅶ activity and factor Ⅶ antigen in patients with hyperlipidemia[J]. J Atheroscler Thromb , 2002,9:72-77.
  • 10Olivotti L, Ghiglitti G, Spallarossa P, et al . High dose of atorvastatin do not affect activity of prothrombinases with acute coronary syndromes[J]. Blood Coagul Fibrinolysis ,2002,13:315-322.

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