宝鸡市丙型肝炎感染因素的病例对照研究

A case-control study on factors of hepatitis C infection in Baoji city of China

目的调查宝鸡市丙型肝炎(简称丙肝)感染的危险因素,为预防控制丙肝的发生提供理论依据。方法采用1∶1个体匹配病例对照设计,对丙肝新发病例及相应的对照进行相同的问卷调查。共发放问卷1 500份,病例、对照各750份。对所有问卷进行整理后,共筛选有效问卷1 321份,其中病例745份,对照576份,将回收的问卷录入数据库后,对调查数据进行单因素和多因素分析,其中单因素分析分为医源性因素和非医源性因素。结果单因素分析结果显示家庭年总收入、共同生活的人患肝炎、母亲患丙肝、共用剃须刀、创伤性美容、修脚、吸毒、性伴患丙肝、输血、使用血制品、手术史、针灸、刮痧、内镜检查、口腔检查等因素有统计学意义,为感染丙肝的危险因素;多因素分析结果显示输血(OR=1.541)、手术(OR=1.225)、口腔检查(OR=1.243)与感染丙肝有较强关联。结论感染丙肝的危险因素有非医源性和医源性两大类。截止目前,宝鸡市丙肝的主要传播途径为通过血液途径的感染,并且以医源性因素为主。

Objective To investigate the risk factors of hepatitis C infections in Baoji city of China.Methods A 1∶1 matched case-control study was conducted with the same questionnaire survey on newly diagnosed cases of hepatitis C and the corresponding controls.After the collected questionnaires were entered into the database,single factor and multi-factor analyses were done and the single factor analysis was divided into iatrogenic factors and non-iatrogenic factors.Results Single factor analysis for total annual household income,living together with hepatitis patients,mother with hepatitis C,shared razors,traumatic beauty,pedicure,drug use,sexual partners with hepatitis C,blood transfusion,blood products,surgical history,acupuncture,scraping,the endoscopic examination,oral examination and other factors showed P-values less than 0.05,indicating as risk factors for hepatitis C infections.Multivariate analysis showed that blood transfusion(OR=1.541),surgery(OR=1.225)and oral examination(OR=1.243)were strongly associated with hepatitis C infection.Conclusions The main routes of hepatitis C infections in Baoji city of China are through blood,and iatrogenic factors.