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乌鲁木齐地区人乳头瘤病毒感染情况及基因型分布 被引量:3

The genotype distributions of HPV infections in Urumqi area of Xinjiang in China
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摘要 目的分析乌鲁木齐地区人乳头瘤病毒(HPV)感染及病毒亚型分布特征。方法收集乌鲁木齐地区2016年12月至2018年6月在新疆维吾尔自治区人民医院皮肤科门诊就诊的709例患者的上皮细胞和组织标本709份,采用实时荧光定量PCR检测HPV DNA并对其进行统计分析。结果 709份标本中HPV检测阳性者483份,阳性率为68.12%,阳性率居前6位的HPV亚型分别为HPV 6型(120/483,24.84%)、11型(38/483,7.87%)、16型(14/483,2.90%)、42型(10/483,2.07%)、59型(8/483,1.66%)、43型(7/483,1.45%),其中单一HPV亚型感染者255例(52.80%),多重亚型混合感染者228例(47.20%)。HPV检测结果各年龄段之间的阳性率差异有统计学意义(χ~2=16.421,P<0.05),40~49岁组阳性率最高,其次为50~59岁、20~29岁,阳性率分别为78.52%、73.08%和66.80%。结论实时荧光定量PCR方法检测人乳头瘤病毒灵敏度高、特异性强,乌鲁木齐地区HPV感染的年龄分布和基因亚型分布具有自身的流行病学特点,针对乌鲁木齐地区HPV各型别进行调查及对各年龄段人群进行筛查对指导HPV疫苗研究以及HPV感染早期预防和治疗具有重要的临床价值。 Objective To study the epidemic status and virus subtype distributions of human papillomavirus(HPV)in Urumqi area of Xinjiang,China.Methods A total of 709 specimen from patients of epithelial exfoliated cells and tissues were collected from December 2016 to June 2018 in the outpatient center of People′s Hospital of Xinjiang Uygur Autonomous Region.Real-time fluorescence quantitative PCR was used for the detection of HPV subtypes.Results The total positive rate was 68.12%(483/709).The top 6 subtypes were HPV6(24.84%),HPV11(7.87%),HPV16(2.90%),HPV42(2.07%),HPV59(1.66%),HPV43(1.45%),and multiple genotype infections was 47.20%(228/483).The highest positive rate of HPV was found in people between 40 to 49 years old(78.52%),then 50-59(73.08%),20-29 years(66.80%).Conclusions The distribution of age and genotypes of HPV infections in the Urumqi area of China showed its regional epidemi-ological characteristics.
作者 胡雯 刘新梅 石岩 康晓静 HU Wen;LIU Xin-mei;SHI Yan;KANG Xiao-jing(People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830001,China)
出处 《中国病毒病杂志》 CAS 2019年第2期149-153,共5页 Chinese Journal of Viral Diseases
关键词 人乳头瘤病毒 基因分型 年龄 感染 Human papillomavirus Genotyping Age Infection
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