通脉益智胶囊对动脉粥样硬化兔大脑中动脉的影响

Effects of Tongmaiyizhi Capsules on the Middle Cerebral Artery in the Rabbit with Atherosclerosis

目的 观察通脉益智胶囊对动脉粥样硬化兔大脑中动脉的影响和作用。方法 2 1只健康雄性日本大白兔按体重随机分为 3组。实验全程 12周 ,光镜下观察兔大脑中动脉的病理学改变 ;扫描电镜下观察大脑中动脉内皮细胞的病理学变化。结果 与胆固醇造模组比较 ,通脉益智胶囊具有明显的保护大脑中动脉内皮细胞和抑制血管平滑肌细胞增殖的作用。结论 通脉益智胶囊具有良好的保护大脑中动脉的作用 。

Objective To observe the effects of Tongmaiyizhi Capsules (TCs) on the middle cerebral artery in the rabbits with atherosclerosis. Methods 21 Healthy Japanese male rabbits were randomly divided into three groups according to their body weights. After 12 weeks of the experiment, the pathologic changes in the middle cerebral artery were observed with the light microscope, and the pathologic changes in the endothelial cells of the middle cerebral artery were observed with the scanning electron microscope. Results TCs showed obvious effects of protecting the endothelial cells of the middle cerebral artery and the effects of inhibiting the proliferation of vascular smooth muscle cells. Conclusion TCs possess rather good effects of protecting the middle cerebral artery, which may be related to their actions of protecting vascular endothelial cells and inhibiting the proliferation of vascular smooth muscle cells.