酸枣仁汤对EPM大鼠血清NO及细胞因子水平的影响

Effects of Suanzaoren Decoction on Serum NO and the Level of Cytokines in Rats

目的 对酸枣仁汤抗焦虑作用的可能机制进行初步探讨。方法 采用国际通用的焦虑动物模型———高架十字迷宫模型 (Theelevatedplus mazetest ,EPM) ,观察酸枣仁汤对EPM大鼠血清NO、IL 1β、IL 6、TNF α等细胞因子水平的影响。 结果 酸枣仁汤 7.5g/(kg·d)能升高EPM焦虑模型大鼠血清NO水平 ,明显改善经高架探究后大鼠血清IL 1β、TNF α水平的降低。 结论 酸枣仁汤抗焦虑作用可能与影响血中NO浓度 ,调节IL 1β、TNF α等细胞因子水平有关。

Objective To initially investigate the possible antianxietic mechanism of Suanzaoren Decoction (SD).Methods The elevated plus maze test (EPM), an internationally universal anxiety model, was used to observe the effects of SD on serum NO and the cytokines, such as IL 1β, IL 6 and TNFαin the rats with EPM.Results It was found that SD could increase the level of serum NO, and restrain the decrease of the levels of IL 1β and TNF α.Conclusion The mechanism of the antianxietic effects of SD may be related to the regulation of the levels of serum NO and cytokines, such as IL 1β and TNF α.