112例大动脉炎临床分析

Clinical Analysis of 112 Patients with Takayasu's Arteritis

目的 探讨大动脉炎的临床特征和活动期治疗方法 ,分析各种治疗方案的疗效及疾病转归。方法 对 112例大动脉炎患者的临床表现、实验室检查、治疗方法和疾病转归进行分析。结果 112例中 ,外科手术治疗 12例 ( 10 .7% ) ;介入治疗 15例 ( 13 .4% ) ,患者病情均无活动 ;激素和 (或 )免疫抑制剂治疗 66例 ( 5 8.9% ) ,其中 5 7例病情活动 ,经治疗后 ,44例病情稳定 ( 77.2 % ) ,7例好转 ( 13 .2 % ) ,6例无效 ( 11.3 % )。结论 大动脉炎临床表现各异 ,治疗方法包括介入治疗、外科手术处理有症状的血管狭窄 ,激素和 (或 )

Objective To investigate the clinical feature and to find out disease therapy mesure.Methods Analysed retrospectively 112 patients with Takayasu's arteritis in Peking Union Medical College since 1990 to 2001.Results Out of 112 patients,15 patients (10.7%) treated with surgical therapy,15 patients(13.4%)had been treated with percutenous transluminal angioplasty(PTCA)with or without stent implantation,and 66 of them used conventional therapy (58.9%) with corticosteroid(CS)with or without cytotoxic agents.Conclusion Takayasu's arteritis is a chronic,idiopathic,inflammatory disease that involved large arteries.Surgical or PCTA treatment are generally recommended during period of presumed remission.Conventional therapy may significantly reduced TA morbidity.CS are the main stay of active TA inflammation,A cytotoxic agent is administered to patients with CS-resistant or relapsing TA.